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STUDY ANALYSES LOW-DOSE ALLERGY REACTIONS TO AID DEVELOPMENT OF PAL

Date Posted May 22nd, 2025.

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Researchers from the Netherlands Organisation for Applied Scientific Research (TNO) and the Food Allergy Research and Resource Program (FARRP) of the University of Nebraska-Lincoln, have analysed thousands of individual threshold data food allergy symptoms held in a database to shed light on the severity of symptoms caused by low doses of allergenic foods.   

The study investigated all symptoms recorded in the TNO-FARRP threshold database occurring at doses ≤ the eliciting dose 10 (≤ED10) for the priority allergenic foods for which population threshold dose distributions have been reported. ED10 is the threshold where up to 10 per cent of allergic individuals exhibit objective symptoms.    

 Almost all of the symptoms in the dose range up to the ED10, and all symptoms in the dose range up to an including the ED05, were mild or moderate and mainly concern subjective or objective symptoms of the skin, eyes or nose, or oral cavity. To a lesser extent, gastro-intestinal or respiratory symptoms were reported. 

The researchers concluded that exposure to doses ≤ ED05 generally results in mild to moderate symptoms for a small subset of allergic individuals.  

Insight into the severity of symptoms at low dose intakes of protein may support decision making and acceptance of harmonized reference doses for Precautionary Allergen Labelling (PAL). A risk-based approach for applying PAL is widely considered a solution for improved protection of food allergic consumers and better-informed food choices. 

Read the paper in full here  

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